Contraction‐associated translocation of protein kinase C in rat skeletal muscle
Authors:
- Erik A. RichterERErik A. Richter
- Stephen RattiganSRStephen Rattigan
- Michael G. ClarkMCMichael G. Clark
- 15 June 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 217 (2) , 232-236
Abstract
Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time‐dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius‐plantaris‐soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction‐initiated changes in muscle metabolism.Keywords
This publication has 15 references indexed in Scilit:
- Inositol 1,4,5-trisphosphate enhances Ca2+-sensitivity of the contractile mechanism of chemically skinned rabbit skeletal muscle fibresBiochemical and Biophysical Research Communications, 1986
- Protein kinase C in cytosol and cell membranes of concanavalin A-stimulated rat thymocytesFEBS Letters, 1986
- Increased Muscle Glucose Uptake After Exercise: No Need for Insulin During ExerciseDiabetes, 1985
- Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.Proceedings of the National Academy of Sciences, 1985
- Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscleNature, 1985
- Phosphorylation of the glucose transporter in vitro and in vivo by protein kinase CNature, 1985
- The role of protein kinase C in cell surface signal transduction and tumour promotionNature, 1984
- Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.Proceedings of the National Academy of Sciences, 1980
- Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase systemBiochemical and Biophysical Research Communications, 1979
- HINDLIMB MUSCLE FIBER POPULATIONS OF FIVE MAMMALSJournal of Histochemistry & Cytochemistry, 1973