An EXAFS study of gold co-ordination in the anti-arthritic drugs Myocrisin and Solganol

Authors:
  • MMMuhammed A. Mazid
    Muhammed A. Mazid
  • MRM. Tahir Razi
    M. Tahir Razi
  • PSPeter J. Sadler
    Peter J. Sadler
  • GGG. Neville Greaves
    G. Neville Greaves
  • SGStephen J. Gurman
    Stephen J. Gurman
  • MKMichel H. J. Koch
    Michel H. J. Koch
  • JPJames C. Phillips
    James C. Phillips
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Abstract
Analysis of the fine structure on the LIIIX-ray absorption edge of Au using calculated phase shifts shows that in disodium thiomalato-S-gold(I)(‘Myocrisin’) and thioglucopyranosyl-S-gold(I)(‘Solganol’) the gold(I) atom is bonded to two (bridging) S atoms 2·37 Å; away; EXAFS spectra are compared with that of Na3Au(S2O3)2, a compound of known structure.