Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury
Authors:
- Miguel A Gama SosaMSMiguel A Gama Sosa
- Rita De GasperiRGRita De Gasperi
- Alejandro J PaulinoAPAlejandro J Paulino
- Paul E PricopPPPaul E Pricop
- Michael C ShaughnessMSMichael C Shaughness
- Eric Maudlin-JeronimoEMEric Maudlin-Jeronimo
- Aaron A HallAHAaron A Hall
- William G M JanssenWJWilliam G M Janssen
- Frank J YukFYFrank J Yuk
- Nathan P DorrNDNathan P Dorr
- Dara L DicksteinDDDara L Dickstein
- Richard M McCarronRMRichard M McCarron
Open Access
- 14 August 2013
- journal article
- Published by Springer Nature in Acta Neuropathologica Communications
- Vol. 1 (1) , 51
Abstract
Blast-related traumatic brain injury (TBI) has been a significant cause of injury in the military operations of Iraq and Afghanistan, affecting as many as 10-20% of returning veterans. However, how blast waves affect the brain is poorly understood. To understand their effects, we analyzed the brains of rats exposed to single or multiple (three) 74.5 kPa blast exposures, conditions that mimic a mild TBI.Keywords
This publication has 33 references indexed in Scilit:
- Development of a Finite Element Model for Blast Brain Injury and the Effects of CSF CavitationAnnals of Biomedical Engineering, 2012
- Acute Blast Injury Reduces Brain Abeta in Two Rodent SpeciesFrontiers in Neurology, 2012
- Porcine Head Response to BlastFrontiers in Neurology, 2012
- Assessment of the Effects of Acute and Repeated Exposure to Blast Overpressure in Rodents: Toward a Greater Understanding of Blast and the Potential Ramifications for Injury in Humans Exposed to BlastFrontiers in Neurology, 2012
- Skull Flexure as a Contributing Factor in the Mechanism of Injury in the Rat when Exposed to a Shock WaveAnnals of Biomedical Engineering, 2011
- Blast-induced Mild Traumatic Brain InjuryPsychiatric Clinics of North America, 2010
- The importance of systemic response in the pathobiology of blast-induced neurotraumaFrontiers in Neurology, 2010
- Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease MutationsThe American Journal of Pathology, 2010
- Traumatic Brain Injury: An Overview of Pathobiology with Emphasis on Military PopulationsJournal of Cerebral Blood Flow & Metabolism, 2009
- A thoracic mechanism of mild traumatic brain injury due to blast pressure wavesMedical Hypotheses, 2009