Interaction of Rifampin and Glucocorticoids

Authors:
  • GBGary A. Buffington
    Gary A. Buffington
  • JDJesus H. Dominguez
    Jesus H. Dominguez
  • WPWalter F. Piering
    Walter F. Piering
  • LHLee A. Hebert
    Lee A. Hebert
  • HKH. Myron Kauffman
    H. Myron Kauffman
  • JLJacob Lemann
    Jacob Lemann
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Abstract
Three renal transplant patients experienced progressive loss of renal allograft function during rifampin treatment forMycobacterium tuberculosis. Previous studies have shown that rifampin causes induction of enzymes in hepatic microsomes that increase the catabolism of glucocorticoids. Evidence is presented that in our patients, the loss of renal allograft function during rifampin therapy was the result of decreased glucocorticoid effect presumably related to increased catabolism of the glucocorticoid drug they received. Thus, the adverse effects of rifampin on renal transplant function might be overcome by increasing the dose of glucocorticoid drug. (JAMA236:1958-1960, 1976)

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