Valproate induced carnitine deficiency and hyperammonaemia
Author:
Open Access
- 31 July 2023
- journal article
- letter
- Published by Elsevier in Clinical Medicine
- Vol. 23 (4) , 429
Abstract
Primary carnitine deficiency is an autosomal recessive inherited metabolic disorder (IMD) affecting the SLC22A5 gene and OCTN2 transporter. Secondary deficiencies are also seen in other IMDs (eg organic acidurias and primary disorders of fatty acid oxidation) or acquired through inadequate dietary intake, renal failure, malabsorption states or are drug induced (eg VPA).Keywords
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