The Detection of Circulating Antibodies Against Antigens from Three Strains of Aspergillus fumigatus*
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Abstract
Summary: One thousand three hundred and ten samples of human sera were studied for the presence of antibodies against Aspergillus fumigatus using antigen extracts from 3 selected strains of A. fumigatus. Fifty sera gave strong precepitin reactions while 221 gave weakly positive reactions. However, only 50 and 11 percent of the strongly positive and weakly positive sera were positive to all 3 extracts. The use of antigenic preparations from several strains of A. fumigatus is proposed to avoid false negative reactions.Zusammenfassung: 1310 Patientenseren wurden auf die Anwesenheit von Antikörpern gegen Aspergillus fumigatus unter Verwendung von Antigenextrakten aus drei ausgewählten Stämmen von Aspergillus fumigatus untersucht. 50 Seren zeigten starke Präzipitinreaktionen, während 221 Seren nur schwach positive Reaktionen aufwiesen. Von den stark bzw. schwach positiven Seren reagierten jedoch nur 50 bzw. 11% auf alle drei Anti‐genextrakte. Es wird daher vorgeschlagen, zur Vermeidung falsch negativer Reaktionen Antigenpräparate von mehreren Aspergillus fumigatus Stämmen gleichzeitig einzusetzen.Keywords
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