Pyrazolylborate−Zinc−Nucleobase-Complexes, 2:1Preparations and Structures of TpCum,MeZn and TpPh,MeZn Complexes
Authors:
- 17 October 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 41 (23) , 6013-6019
Abstract
The interactions of the nine most significant nucleobases (thymine, uracil, dihydrouracil, cytosine, adenine, guanine, diaminopurine, xanthine, hypoxanthine, in their deprotonated forms) with zinc and with themselves in pyrazolylborate zinc complexes TpCum,MeZn−base and TpPh,MeZn−base are described. Except for guanine, the complexes Tp*Zn−base could be isolated in all cases. Structure determinations could be performed for seven of the eight product types. Except for dihydrouracil and xanthine, the zinc ion is attached to that nitrogen of the base which in nucleosides bears the sugar moiety. In the solid state, all zinc-bound nucleobases are involved in hydrogen bonding interactions. Except for xanthine, this includes homo base pairing across a crystallographic inversion center.Keywords
This publication has 47 references indexed in Scilit:
- Macrocyclic zinc(II) complexes for selective recognition of nucleobases in single- and double-stranded polynucleotidesJBIC Journal of Biological Inorganic Chemistry, 1998
- Pyrazolylborate−Zinc Complexes of RNA Precursors and Analogues ThereofInorganic Chemistry, 1997
- Small Molecule Chemistry of the Pyrazolylborate−Zinc Unit TpCum,MeZnInorganic Chemistry, 1996
- Pyrazolylborat‐Zinkkomplexe mit Medikament‐LigandenEuropean Journal of Inorganic Chemistry, 1994
- Models for the interaction of zinc(2+) with DNA. Syntheses and x-ray structural characterizations of two polymeric tetrahedral zinc complexes of monomethyl phosphate esters of cytidine and deoxycytidine 5'-monophosphate nucleotidesInorganic Chemistry, 1986
- Stereoselectivity in the binding of transition-metal chelate complexes to nucleic acid constituents: bonding and nonbonding effectsAccounts of Chemical Research, 1977
- The crystal structure of guanine monohydrateActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1971
- Tautomeric forms and ionisation processes in xanthine and its N-methyl derivativesJournal of the Chemical Society C: Organic, 1971
- Stereochemistry of nucleic acids and their constituents. VI. The crystal structure and conformation of dihydrouracil: a minor base of transfer-ribonucleic acidActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1970
- X-Ray crystal structures of zinc–adenine and zinc–guanine complexesJournal of the Chemical Society D: Chemical Communications, 1970