Methods of Inducing Inflammatory Bowel Disease in Mice
Authors:
Open Access
- 18 March 2016
- journal article
- unit
- Published by Wiley in Current Protocols in Pharmacology
- Vol. 72 (1) , 5.58.1-5.58.42
Abstract
Animal models of experimentally induced inflammatory bowel disease (IBD) are useful for understanding more about the mechanistic basis of the disease, identifying new targets for therapeutic intervention, and testing novel therapeutics. This unit provides detailed protocols for five widely used mouse models of experimentally induced intestinal inflammation: chemical induction of colitis by dextran sodium sulfate (DSS), hapten‐induced colitis via 2,4,6‐trinitrobenzene sulfonic acid (TNBS), Helicobacter‐induced colitis in mdr1a −/− mice, the CD4+ CD45RBhi SCID transfer colitis model, and the IL‐10−/− colitis model. © 2016 by John Wiley & Sons, Inc.Keywords
This publication has 67 references indexed in Scilit:
- New Insights into the Immunological Changes in IL-10-Deficient Mice during the Course of Spontaneous Inflammation in the Gut MucosaJournal of Immunology Research, 2012
- Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative ColitisGastroenterology, 2010
- Inflammatory Bowel DiseaseNew England Journal of Medicine, 2009
- Gnotobiotic IL-10−/−; NF-κBEGFP Mice Develop Rapid and Severe Colitis Following Campylobacter jejuni InfectionPLOS ONE, 2009
- T cell transfer model of chronic colitis: concepts, considerations, and tricks of the tradeAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2009
- TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 ActivationGastroenterology, 2008
- Chemically induced mouse models of intestinal inflammationNature Protocols, 2007
- Helicobacter bilis triggers persistent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H/HeN miceGut, 2006
- Interferon-gamma is causatively involved in experimental inflammatory bowel disease in miceClinical and Experimental Immunology, 2006
- Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.Journal of Clinical Investigation, 1996