Thienopyrrole-expanded BODIPY as a potential NIR photosensitizer for photodynamic therapy
Authors:
- 13 March 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 49 (38) , 3940-3942
Abstract
The synthesis and characterization of a highly photostable bromo-substituted BODIPY dye (I) fused-ring-expanded with thienopyrrole moieties is reported. The results of MTT assays and flow cytometric analyses in living HeLa cells demonstrate that I has a high singlet oxygen quantum yield (ΦΔ = 0.63) and exhibits photocytotoxicity upon irradiation in the NIR region making it potentially suitable for use in PDT.Keywords
This publication has 52 references indexed in Scilit:
- Encapsulated Energy-Transfer Cassettes with Extremely Well Resolved Fluorescent OutputsJournal of the American Chemical Society, 2010
- Selective Hg(II) Sensing with Improved Stokes Shift by Coupling the Internal Charge Transfer Process to Excitation Energy TransferOrganic Letters, 2010
- Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and OptimizationChemical Reviews, 2010
- Fluorescent Cassettes for Monitoring Three-Component Interactions in Vitro and in Living CellsJournal of the American Chemical Society, 2009
- The present and future role of photodynamic therapy in cancer treatmentThe Lancet Oncology, 2004
- A Blue-to-Red Energy-Transfer Thymidine Analogue That Functions in DNAOrganic Letters, 2004
- Photodynamic therapy for cancerNature Reviews Cancer, 2003
- Basic principles of photodynamic therapyJournal of Porphyrins and Phthalocyanines, 2001
- Photodynamic therapeutics: basic principles and clinical applicationsDrug Discovery Today, 1999
- Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapyChemical Society Reviews, 1995