Complement factor H variant Y402H and basal laminar deposits in exudative age-related macular degeneration
- 18 August 2007
- journal article
- research article
- Published by Springer Nature in Graefe's Archive for Clinical and Experimental Ophthalmology
- Vol. 245 (11) , 1713-1716
Abstract
Complement factor H (CFH) polymorphism Y402H has been shown to be significantly associated with age-related macular degeneration (AMD). Furthermore, histopathological studies in AMD have implicated basal laminar deposits (BLD) in the development of choroidal neovascularization (CNV) membranes. The purpose of this study was to correlate CFH staining in BLD with the CFH genotype at the tyrosine 402 histidine (Y402H) polymorphism.Keywords
This publication has 19 references indexed in Scilit:
- CFH Y402H Confers Similar Risk of Soft Drusen and Both Forms of Advanced AMDPLOS Medicine, 2005
- Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease riskHuman Molecular Genetics, 2005
- Strong Association of the Y402H Variant in Complement Factor H at 1q32 with Susceptibility to Age-Related Macular DegenerationThe American Journal of Human Genetics, 2005
- Complement Factor H Polymorphism in Age-Related Macular DegenerationScience, 2005
- Complement Factor H Variant Increases the Risk of Age-Related Macular DegenerationScience, 2005
- Complement Factor H Polymorphism and Age-Related Macular DegenerationScience, 2005
- Clinicopathological correlation in exudative age related macular degeneration: histological differentiation between classic and occult choroidal neovascularisationBritish Journal of Ophthalmology, 2000
- Clinicopathologic correlations of surgically excised type 1 and type 2 submacular choroidal neovascular membranesAmerican Journal of Ophthalmology, 1998
- Clinical Characteristics of Choroidal Neovascular MembranesArchives of Ophthalmology (1950), 1987
- Ageing and degeneration in the macular region: a clinico-pathological study.British Journal of Ophthalmology, 1976