Reference equine antisera to 33 human adenovirus types: homologous and heterologous titers

Authors:
  • JHJ C Hierholzer
    J C Hierholzer
  • WGW C Gamble
    W C Gamble
  • WDW R Dowdle
    W R Dowdle
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Abstract
Equine antisera to human adenovirus types 1 to 33 were prepared and evaluated by hemagglutination-inhibition and serum neutralization tests. Detailed data on the potency and purity of the immunizing antigens were tabulated as one means of evaluating the antisera. Most of the 52 hemagglutination-inhibition and 25 serum neutralization major or minor heterotypic responses among the equine antisera were observed at similar levels in previous studies with rabbit antisera and appeared to represent genuine antigenic relationships among the human adenoviruses. Equine antisera to human adenoviruses 1 to 33 and a similarly packaged normal horse serum served as lots of fully tested sera for definitive typing of isolates and as reference standards for evaluating other antisera.

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