Brain histamine receptors as targets for antidepressant drugs
Authors:
- Philip D. KanofPKPhilip D. Kanof
- Paul GreengardPGPaul Greengard
- 1 March 1978
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 272 (5651) , 329-333
Abstract
A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain. This common biochemical action may represent part of the molecular basis for the antidepressant properties of these compounds.Keywords
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