There's Many a Slip 'twixt Implantation and the Crib

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  • ALA. Brian Little
    A. Brian Little
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Abstract
Between fertilization and implantation and the clinical identification of pregnancy there is a period of hazard and potential pregnancy loss. Pregnancy loss during this period is usually classified as occult abortion or "chemical beta human chorionic gonadotropin (ß hCG) abortion" (implying a positive pregnancy test with or without delayed bleeding). The study by Wilcox et al.1 in this issue of the Journal assesses such pregnancy loss with a sensitive urinary immunoradiometric assay2 in 230 healthy women. The assay is a test with exquisite specificity and sensitivity that measures intact hCG plus some free beta-subunit radicals without cross-reaction with luteinizing hormone. . . .

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