Aromatase and Sulfatase Inhibitors fromLepiota americana

Authors:
  • DKDong-Seon Kim
    Dong-Seon Kim
  • HJHyeh-Jean Jeong
    Hyeh-Jean Jeong
  • KBKrishna Bhat
    Krishna Bhat
  • SPSo-Young Park
    So-Young Park
  • SKSoo-Hyon Kang
    Soo-Hyon Kang
  • EYEun-Hwa Yoo
    Eun-Hwa Yoo
  • MLMinna Lee
    Minna Lee
  • HLHang-Woo Lee
    Hang-Woo Lee
  • RKRobert Krueger
    Robert Krueger
  • DKDarrick Kim
    Darrick Kim
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Abstract
From an edible mushroom Lepiota americana Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC50 = 5.7µM and 3β-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC50 = 0.9µM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3β-hydroxy-5,8-epidioxyergosta- 6,22-diene active against aromatase.