Insulin-like growth factor-II: new roles for an old actor
Open Access
- 1 January 2012
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Endocrinology
- Vol. 3, 34995
Abstract
Insulin-like growth factor-II (IGF-II), traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator. The aim of this overview is to provide the available evidence, obtained in both experimental conditions and in humans, for a role of IGF-II in the fine-tuning of metabolism and body composition. The underlying mechanisms and the potential clinical implications are discussed.Keywords
This publication has 57 references indexed in Scilit:
- Gene Expression Profiling of Neural Stem Cells and Their Neuronal Progeny Reveals IGF2 as a Regulator of Adult Hippocampal NeurogenesisJournal of Neuroscience, 2012
- Associations Between Paternally Transmitted Fetal IGF2 Variants and Maternal Circulating Glucose Concentrations in PregnancyDiabetes, 2011
- Long Range Interactions Regulate Igf2 Gene Transcription during Skeletal Muscle DifferentiationJournal of Biological Chemistry, 2010
- Persistent epigenetic differences associated with prenatal exposure to famine in humansProceedings of the National Academy of Sciences, 2008
- Insulin-Like Growth Factors in the Peripheral Nervous SystemEndocrinology, 2008
- A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pigNature, 2003
- Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11Human Genetics, 2002
- Neuroblastoma and insulin-like growth factor systemEuropean Journal of Pediatrics, 1997
- Localization of insulin-like growth factor genes to human chromosomes 11 and 12Nature, 1984
- Ontogenesis of somatomedin and insulin receptors in the human fetus.Journal of Clinical Investigation, 1983