Synthesis of Functionalized Oxacalix[4]arenes
- 8 December 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (1) , 91-94
Abstract
Tetranitrooxacalix[4]arenes are generated in high yield by the room-temperature S(N)Ar reaction of 1,3-dihydroxybenzenes with 1,5-difluoro-2,4-dinitrobenzene. The reaction is tolerant to a range of functionality on the nucleophilic component, including hydroxyl-substitution at the 2- and 5-positions, which yields previously unknown 26,28- and 5,17-dihydroxyoxacalix[4]arenes.Keywords
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