NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties.

Authors:
  • MMMasafumi Maruhashi
    Masafumi Maruhashi
  • NSNoriyoshi Sakai
    Noriyoshi Sakai
  • KMKazutoshi Mizoue
    Kazutoshi Mizoue
  • KHKazunori Hanada
    Kazunori Hanada
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Abstract
NG-011 and NG-012, novel potentiators of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542, together with 3,4-dihydro-6,8-dihydroxy-3-methylisocoumarin. They potentiated the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12).