Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis

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Open Access

1 January 2007

journal article
research article
Published by Springer Nature in BMC Molecular Biology

Vol. 8 (1) , 52
DOI:10.1186/1471-2199-8-52
PMID:17584492
PMCID:PMC1914352

Abstract

With the advent of sequence-based approaches in the mutagenesis studies, it is now possible to directly evaluate the genome-wide pattern of experimentally induced DNA sequence changes for a diverse array of organisms. To gain a more comprehensive understanding of the mutational bias inherent in mouse ENU mutagenesis, this study describes a detailed evaluation of the induced mutational pattern obtained from a sequence-based screen of ENU-mutagenized mice.

Keywords

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