Biosynthesis of vitamin B6. Incorporation of glycolaldehyde into pyridoxal

Authors:
  • RHRobert E. Hill
    Robert E. Hill
  • PHPeter Horsewood
    Peter Horsewood
  • ISIan D. Spenser
    Ian D. Spenser
  • YTYoshiki Tani
    Yoshiki Tani
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Abstract
Radioactivity from [14C]glycolaldehyde enters pyridoxal phosphate specifically, and is confined to the two-carbon unit C(5)–C(5′). Glycolaldehyde enters as an intact two-carbon unit, the aldehyde carbon atom supplying C-5, and the carbinol carbon atom C-5′ of the vitamin. These observations are interpreted in terms of the early stages of the biosynthesis of vitamin B6.