Deregulation of H3K27 methylation in cancer
- 1 February 2010
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 42 (2) , 100-101
Abstract
A new study now reports recurrent somatic mutation of EZH2, a histone methyltransferase that modifies H3K27, in diffuse large B-cell lymphoma (DLBCL). There is now evidence for both increased and decreased activity of enzymes controlling H3K27 methylation in cancer, suggesting that a precise balance of this methylation is critical for normal cell growth.Keywords
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