Triptolide Loaded Solid Lipid Nanoparticle Hydrogel for Topical Application

Authors:
  • QWQunrong Wu
    Qunrong Wu
  • SHSheng Hu
    Sheng Hu
  • XLXiaokuan Lib
    Xiaokuan Lib
  • XYXiangliang Yang
    Xiangliang Yang
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Abstract
Triptolide (TP) has been shown to have anti-inflammatory, antifertility, antineoplastic, and immunosuppressive activity. However, its clinical usage is limited to some extent due to its poor water solubility and toxicity. In order to use innovative ways to administer TP and to overcome or alleviate its disadvantages, controlled-release delivery systems such as solid lipid nanoparticle(SLN(s)) have been developed. In the present paper we describe the preparation and some characterization of specialized delivery systems for TP. The transdermal delivery and anti-inflammatory activity were also evaluated. The results indicated that SLN could serve as an efficient promoter of TP penetrating into skin. Furthermore, different formulations were optimized in this study. The best formulation of SLN, consisted of tristearin glyceride, soybean lecithin, and PEG400MS, with a particle size of 123 ± 0.9 nm, polydispersity index (PI) of 0.19, and zeta potential of − 45 mV. When this SLN dispersion was incorporated into h...

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