Abstract
A vast amount of evidence, not directly included in randomized controlled studies, points towards a number of important physiological and pharmacological effects of vitamin D, although the minimal physiological substitution dosage needs to be determined. No doubt that the balance of treating patients with vitamin D is difficult and that overtreatment might lead to negative responses such as extraskeletal vascular calcifications, etc., but that risk is today well known to most nephrologists and does not outdo the beneficial potential. Conflict of interest statement. None declared.
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