Descemet Stripping Automated Endothelial Keratoplasty After Failed Penetrating Keratoplasty

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Abstract
Descemet stripping automated endothelial keratoplasty (DSAEK) has become the first-line treatment for corneal endothelial failure. In comparison with penetrating keratoplasty (PK), DSAEK results in less induced astigmatism and eliminates suture-related complications.1 Because of these advantages, DSAEK has become, for many corneal surgeons, the preferred means of managing PK failure secondary to isolated endothelial dysfunction, particularly in cases in which the failed PK had healed with a satisfactory refractive shape profile. The DSAEK procedure also may be associated with a lower endothelial rejection rate than PK.2-4 However, comparative studies5,6 to date have focused on eyes in which DSAEK was the primary corneal procedure, and differing topical corticosteroid regimens in the PK and DSAEK groups may have influenced the results.

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