Lipid nanoparticles-loaded with toxin mRNA represents a new strategy for the treatment of solid tumors
Authors:
Open Access
- 12 June 2023
- journal article
- research article
- Published by Ivyspring International Publisher in Theranostics
- Vol. 13 (11) , 3497-3508
Abstract
Background and rationale: Cancer therapy have evolved remarkably over the past decade, providing new strategies to inhibit cancer cell growth using immune modulation, with or without gene therapy. Specifically, suicide gene therapies and immunotoxins have been investigated for the treatment of tumors by direct cancer cell cytotoxicity. Recent advances in mRNA delivery also demonstrated the potential of mRNA-based vaccines and immune-modulators for cancer therapeutics by utilizing nanocarriers for mRNA delivery.Keywords
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