Ultra-selective and sensitive DNA detection by a universal apurinic/apyrimidinic probe-based endonuclease IV signal amplification system
Authors:
- 25 October 2011
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 48 (14) , 1964-1966
Abstract
A novel signal amplification system that is applicable to any DNA sequence of interest has been developed by using a combination of apurinic/apyrimidinic probe and endonuclease IV. The system allows rapid, highly selective and sensitive detection of target DNA sequences at very low concentrations (10 fmol) or low abundance levels (1%).Keywords
This publication has 16 references indexed in Scilit:
- Sensitive and Selective Amplified Fluorescence DNA Detection Based on Exonuclease III-Aided Target RecyclingJournal of the American Chemical Society, 2010
- Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle AmplificationAngewandte Chemie International Edition, 2009
- Low‐Noise Stemless PNA Beacons for Sensitive DNA and RNA DetectionAngewandte Chemie International Edition, 2008
- Pyramidal Lead Sulfide Crystallites With High Energy {113} FacetsJournal of the American Chemical Society, 2008
- Sequence specific detection of DNA using nicking endonuclease signal amplification (NESA)Nucleic Acids Research, 2007
- Dual-labeled oligonucleotide probe for sensing adenosine via FRET: A novel alternative to SNPs genotypingChemical Communications, 2007
- Human cancers express a mutator phenotypeProceedings of the National Academy of Sciences, 2006
- Structure of the DNA Repair Enzyme Endonuclease IV and Its DNA ComplexCell, 1999
- Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosisNature Biotechnology, 1998
- Molecular Beacons: Probes that Fluoresce upon HybridizationNature Biotechnology, 1996