TFIIB and the regulation of transcription by RNA polymerase II
- 26 June 2007
- journal article
- review article
- Published by Springer Nature in Chromosoma
- Vol. 116 (5) , 417-429
Abstract
Accurate transcription of a gene by RNA polymerase II requires the assembly of a group of general transcription factors at the promoter. The general transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA polymerase II. TFIIB makes extensive contact with the core promoter via two independent DNA-recognition modules. In addition to interacting with other general transcription factors, TFIIB directly modulates the catalytic center of RNA polymerase II in the transcription complex. Moreover, TFIIB has been proposed as a target of transcriptional activator proteins that act to stimulate preinitiation complex assembly. In this review, we will discuss our current understanding of these activities of TFIIB.Keywords
This publication has 130 references indexed in Scilit:
- Repression of the human dihydrofolate reductase gene by a non-coding interfering transcriptNature, 2007
- Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase IIEMBO Reports, 2006
- The General Transcription Machinery and General CofactorsCritical Reviews in Biochemistry and Molecular Biology, 2006
- Ssu72 Is an RNA Polymerase II CTD PhosphataseMolecular Cell, 2004
- The VP16 Activation Domain Interacts with Multiple Transcriptional Components as Determined by Protein-Protein Cross-linking in VivoJournal of Biological Chemistry, 2002
- Sequence-Specific DNA Binding by the S. shibatae TFIIB Homolog, TFB, and Its Effect on Promoter StrengthMolecular Cell, 1998
- Crystal structure of a TFIIB–TBP–TATA-element ternary complexNature, 1995
- A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulationCurrent Biology, 1995
- Activator-induced conformational change in general transcription factor TFIIBNature, 1994
- An RNA polymerase II holoenzyme responsive to activatorsNature, 1994