Arterial stiffness precedes hypertension and metabolic risks in youth: a review
Open Access
- 11 July 2022
- journal article
- review article
- Published by Wolters Kluwer Health in Journal Of Hypertension
- Vol. 40 (10) , 1887-1896
Abstract
Arterial stiffness is a strong predictor of cardiovascular events and all-cause mortality in middle-aged and old adults. Arterial stiffness has been limited to being an intermediate marker of atherosclerotic cardiovascular events in adolescents and young adult studies. The paucity of normative longitudinal data and repeated gold-standard assessments of arterial stiffness among the young population has occasioned a huge knowledge gap in its clinical utility. This review summarizes recent longitudinal evidence in a large adolescent population, supporting the value of arterial stiffness as a novel risk factor for hypertension, overweight/obesity and insulin resistance. Preventing or decreasing arterial stiffness during adolescence may confer cardiometabolic health benefits in later life, but further pathological and mechanistic research is needed. The review also offers suggestions for incorporating arterial stiffness measures into routine paediatric and young adult clinical practice.Keywords
This publication has 93 references indexed in Scilit:
- Evolution of the Arterial Structure and Function From Infancy to Adolescence Is related to Anthropometric and Blood Pressure ChangesArteriosclerosis, Thrombosis, and Vascular Biology, 2012
- Insulin resistance and arterial stiffness in healthy adolescents and young adultsDiabetologia, 2011
- Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient miceAmerican Journal of Physiology-Heart and Circulatory Physiology, 2011
- Increased arterial stiffness is found in adolescents with obesity or obesity-related type 2 diabetes mellitusJournal Of Hypertension, 2010
- Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’European Heart Journal, 2010
- Lifetime Risk Factors and Arterial Pulse Wave Velocity in AdulthoodHypertension, 2010
- Sodium Intake and Vascular Stiffness in HypertensionHypertension, 2009
- Arterial Aging and Subclinical Arterial Disease are Fundamentally Intertwined at Macroscopic and Molecular LevelsMedical Clinics of North America, 2009
- Heritability and a Genome-Wide Linkage Scan for Arterial Stiffness, Wave Reflection, and Mean Arterial PressureCirculation, 2005
- Arterial Stiffness and HypertensionHypertension, 2005