EFFECTS OF NOISE ON BLOOD PRESSURE AND VASCULAR REACTIVITIES
Authors:
- 1 December 1992
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 19 (12) , 833-838
Abstract
SUMMARY: 1. The present study investigated the effects of noise stress (100 dB, 1 kHz, 4 h/day, 6 days/ week) on both systolic blood pressure and vascular reactivities in rats exposed to noise for 2 and 4 weeks. The systolic blood pressure was significantly increased after rats were exposed to noise for 4 weeks but not 2 weeks.2. In isolated thoracic aortic rings, the responses to serotonin were enhanced in noise‐treated rats while there were no changes in response to phenylephrine and high K4between noise‐treated and control rats.3. The relaxant responses to endothelium‐dependent vasodilators (A23187 and acetylcholine) in noise‐treated rats were less than those in control rats. The vasodilator responses to acetylcholine were completely abolished by methylene blue or Nω‐nitro‐L‐arginine.4. Responses to the endothelium‐independent vasodilator, nitroglycerin, were not significantly changed after rats were exposed to noise.5. The enhanced response to vasoconstrictors and the attenuation to endothelium‐dependent vasodilators may account for elevations in blood pressure during noise stress. This indicates that the elevation in blood pressure by noise stress may be partly due to the deterioration of endothelial function.Keywords
This publication has 23 references indexed in Scilit:
- Calcium ionophore and acetylcholine dilate arterioles on the mouse brain by different mechanisms.Stroke, 1989
- Ultrastructural studies of pial vascular endothelium following damage resulting in loss of endothelium-dependent relaxation.Stroke, 1987
- Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.Journal of Clinical Investigation, 1987
- The loss of endothelium-dependent vascular relaxation in hypertension.Hypertension, 1986
- Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.Hypertension, 1983
- Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotoninNature, 1983
- Circulatory Effects of NoiseActa Medica Scandinavica, 1983
- Peripheral Vasoconstriction In The Rat In Response To Sound: II. Dependence On Rate Of Change Of Sound LevelActa Oto-Laryngologica, 1978
- Peripheral Vasoconstriction in the Rat in Response to Sound: III. Dependence on Pause Characteristics in Continuous NoiseActa Oto-Laryngologica, 1978
- PROLONGED EXPOSURE TO A STRESSFUL STIMULUS (NOISE) AS A CAUSE OF RAISED BLOOD-PRESSURE IN MANThe Lancet, 1977