The Hepatic Chalone. I. Assay Method for the Hormone and Purification of the Rabbit Liver Chalone

Authors:
  • WVW. G. Verly
    W. G. Verly
  • YDY. Deschamps
    Y. Deschamps
  • JPJ. Pushpathadam
    J. Pushpathadam
  • MDM. Desrosiers
    M. Desrosiers
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Abstract
Chalone from rabbit liver has been purified 450-fold; it is a polypeptide of small molecular weight. Its action on liver DNA synthesis is tissue-specific but not species-specific. The dose–effect relationship is in agreement with the theory of receptor sites in the hepatocytes with a low affinity for this hormone.