Neutrophil Activation in Thermal Injury as Assessed by Increased Expression of Complement Receptors
Authors:
- Francis D. MooreFMFrancis D. Moore
- Carl DavisCDCarl Davis
- Mary RodrickMRMary Rodrick
- John A. MannickJMJohn A. Mannick
- Douglas T. FearonDFDouglas T. Fearon
- 10 April 1986
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 314 (15) , 948-953
Abstract
We studied neutrophil activation in patients with burns by serial immunofluorescent measurement of neutrophil expression of the complement opsonin receptors CR1 and CR3. CR1-dependent fluorescence was initially (days 0 through 5 after the burn) elevated (mean ±SEM, 294±42 vs. 63±6 in the controls; P<0.001) and gradually returned to normal (days 6 through 8, 270±62, P<0.001; days 9 through 13, 185±38, P<0.001; days 14 through 19, 143±27, P<0.001; and days 20 through 50, 93±5, P<0.04). CR3-dependent fluorescence paralleled that of CR1.Keywords
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