Why do workload spikes cause injuries, and which athletes are at higher risk? Mediators and moderators in workload–injury investigations

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Abstract
Like dominoes being knocked over, mediators can be viewed as the intermediary steps that explain the association between an observed variable and an outcome.4 In this context, mediating variables help to explain ‘why changes in workloads might cause injuries?’ For example, it is known that rugby league players exposed to spikes in running workloads, indicated by a high acute:chronic workload ratio, are at an increased risk for non-contact injuries.5 One potential explanation is that neuromuscular fatigue mediates this relationship, such that increased …

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