Age-correlated stress resistance improves fitness of yeast: support from agent-based simulations
Open Access
- 1 January 2014
- journal article
- Published by Springer Nature in BMC Systems Biology
- Vol. 8 (1) , 18
Abstract
Resistance to stress is often heterogeneous among individuals within a population, which helps protect against intermittent stress (bet hedging). This is also the case for heat shock resistance in the budding yeast Saccharomyces cerevisiae. Interestingly, the resistance appears to be continuously distributed (vs. binary, switch-like) and correlated with replicative age (vs. random). Older, slower-growing cells are more resistant than younger, faster-growing ones. Is there a fitness benefit to age-correlated stress resistance?Keywords
This publication has 55 references indexed in Scilit:
- Mighty small: Observing and modeling individual microbes becomes big scienceProceedings of the National Academy of Sciences, 2013
- Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platformProceedings of the National Academy of Sciences, 2012
- Exploiting the determinants of stochastic gene expression in Saccharomyces cerevisiae for genome-wide prediction of expression noiseProceedings of the National Academy of Sciences, 2010
- Slow Growth Induces Heat-Shock Resistance in Normal and Respiratory-deficient YeastMolecular Biology of the Cell, 2009
- Selective benefits of damage partitioning in unicellular systems and its effects on agingProceedings of the National Academy of Sciences, 2008
- Molecular eco-systems biology: towards an understanding of community functionNature Reviews Microbiology, 2008
- Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiaeProceedings of the National Academy of Sciences, 2007
- Noise in protein expression scales with natural protein abundanceNature Genetics, 2006
- Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noiseNature, 2006
- BacSim, a simulator for individual-based modelling of bacterial colony growthMicrobiology, 1998