Ruthenium–NHC–Diamine Catalyzed Enantioselective Hydrogenation of Isocoumarins
- 8 February 2017
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 139 (7) , 2585-2588
Abstract
A novel and practical chiral ruthenium–NHC–diamine system is disclosed for the enantioselective hydrogenation of isocoumarins, which provides a new concept to apply (chiral) NHC ligands in asymmetric catalysis. A variety of optically active 3-substituted 3,4-dihydroisocoumarins were obtained in excellent enantioselectivities (up to 99% ee). Moreover, this methodology was utilized in the synthesis of O-methylmellein, mellein, and ochratoxin A.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft
- Studienstiftung des Deutschen Volkes
- Alexander von Humboldt-Stiftung
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