Recognition of guanines at a double helix–coil junction in DNA by a trinuclear copper complex
- 31 August 2005
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 38,p. 4812-4814
Abstract
Coordination between guanine N7 and a trinuclear copper complex appears critical for selective and efficient strand scission of DNA at a helix–coil junction as indicated by the lack of reactivity of comparable DNA containing 7-deazaguanine in place of guanine; both the base pair at the junction and coil flexibility also modulate the specificity of DNA oxidation.Keywords
This publication has 22 references indexed in Scilit:
- Synthetic metallonucleases for RNA cleavageCurrent Opinion in Chemical Biology, 2004
- A Minor Groove Binding Copper-Phenanthroline Conjugate Produces Direct Strand Breaks via β-Elimination of 2-DeoxyribonolactoneJournal of the American Chemical Society, 2002
- Chemical nucleasesCurrent Opinion in Chemical Biology, 2001
- Oxidative Nucleobase Modifications Leading to Strand ScissionChemical Reviews, 1998
- Model Studies Indicate That Copper Phenanthroline Induces Direct Strand Breaks via β-Elimination of the 2‘-Deoxyribonolactone Intermediate Observed in Enediyne Mediated DNA DamageJournal of the American Chemical Society, 1998
- DNA And RNA Cleavage by Metal Complexes1998
- Electron-, Energy-, and Atom-Transfer Reactions Between Metal Complexes and DnaAdvances in Inorganic Chemistry, 1995
- Recognition of Guanine Structure in Nucleic Acids by Nickel ComplexesAccounts of Chemical Research, 1994
- Chemical nucleasesChemical Reviews, 1993
- Targeted chemical nucleasesAccounts of Chemical Research, 1993