CYP gene family variants as potential protective factors in drug addiction in Han Chinese

Authors:
Publisher website
Google Scholar
Abstract
Background: There is growing evidence that genetic factors also contribute to drug addiction. The human cytochrome P450 has shown special interest because of pharmacokinetic variation in different individuals and populations, which is largely determined by the relevant genes. The present study aimed to investigate the polymorphism of the CYP/addicts relationship.Methods: We genotyped 13 tag single‐nucleotide polymorphisms (tSNPs) from three genes, including 692 cases and 700 controls. Sequenom MassARRAY RS1000 (Sequenom, Inc., San Diego, CA, USA) was used for SNP genotyping. Statistical analysis of the association between tSNPs and drug addiction was performed using the chi‐squared test and SNP Stats software (http://bioinfo.iconcologia.net).Results: The T/T genotype of rs2242480 inCYP3A4was associated with decreased risk in the recessive model (p= 0.0002). Allele frequency at rs3743484 inCYP1A2showed significant differences between addicts and controls (p= 0.046; odds ratio = 0.80; 95% confidence interval = 0.65–1.00). In genetic model analyses, the minor C allele of rs3743484 inCYP1A2was associated with a reduced risk of drug addiction based on analysis using codominant and additive models (p= 0.027 dominant model;p=0.038 additive model).Conclusions: Our findings show that at allelic and genotypic level polymorphisms inCYP3A4andCYP1A2are significantly associated with a reduced risk of drug addiction in X'ian Han Chinese individuals. However, this result needs to be confirmed in additional studies. Copyright © 2016 John Wiley & Sons, Ltd.

This publication has 28 references indexed in Scilit: