Physicochemical, Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Tacrolimus (FK 506) in Rats
Authors:
- 1 July 1995
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 12 (7) , 1055-1059
Abstract
Purpose. Tacrolimus (FK 506) is a new potent immunosuppressant. Because of poor water solubility, the conventional intravenous dosage forms of FK 506 (C-FK 506) contain surfactants such as HCO-60...Keywords
This publication has 26 references indexed in Scilit:
- Pharmacokinetics of tacrolimus in liver transplant patients*Clinical Pharmacology & Therapeutics, 1995
- Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye.1993
- THE HEMODYNAMIC EFFECTS OF CREMOPHOR-ELTransplantation, 1991
- Pharmacokinetics and in vivo activity of liposome-encapsulated gentamicinAntimicrobial Agents and Chemotherapy, 1990
- CHOLESTASIS IN THE RAT BY MEANS OF INTRAVENOUS ADMINISTRATION OF CYCLOSPORINE VEHICLE, CREMOPHOR ELTransplantation, 1989
- Synergistic antifungal activity and reduced toxicity of liposomal amphotericin B combined with gramicidin S or NFAntimicrobial Agents and Chemotherapy, 1987
- USE OF THE ISOLATED PERFUSED KIDNEY MODEL TO ASSESS THE ACUTE PHARMACOLOGIC EFFECTS OF CYCLOSPORINE AND ITS VEHICLE, CREMOPHOR ELTransplantation, 1987
- Modulation of histamine release from rat peritoneal mast cells by non-cytotoxic concentrations of the detergents Cremophor El® (oxethylated castor oil) and Triton X100. A possible explanation for unexpected adverse drug reactions?Inflammation Research, 1986
- Comparison of the histamine-releasing activity of cremophor El® and some of its derivatives in two experimental models: Thein vivo anaesthetized dog andin vitro rat peritoneal mast cellsInflammation Research, 1985
- Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1979