Association of HLA‐DQB1★0301 and HLA‐DQB1★0602 with Different Subtypes of Gastric Cancer in Taiwan

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Abstract
Gastric cancer (GC) is a heterogeneous disorder with multifactorial etiologies. Genetic predisposition, environmental factors, and Helicobacter pylori infection are thought to interact in the manifestation of GC. Particular human leukocyte antigen (HLA) alleles play a pivotal role in cellular immunity and may be an important genetically determined host trait. To elucidate the association between the genotype of HLA class II genes and the clinical phenotype of GC, polymorphisms of HLA‐DRB1 and HLA‐DQB1 were determined by polymerase chain reaction with sequence‐specific primers in 106 Taiwanese patients with GC and in 208 healthy controls. Comparison of allele frequencies between GC patients and healthy controls showed no significant difference at the HLA‐DRB1 locus. Patients with GC had a higher frequency of DQB1★0602 (9.4% vs. 3.6%, PPPPPHelicobacter pylori (14/30 vs. 58/76, PHelicobacter pyloriinfection. HLA‐DQB1 alleles are associated with susceptibility or resistance to GC and also influence its clinical features.

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