Responses of isolated human basilar arteries to 5-hydroxytryptamine, noradrenaline, serum, platelets, and erythrocytes.
Authors:
- L M StarlingLSL M Starling
- D J BoullinDBD J Boullin
- D G Grahame-SmithDGD G Grahame-Smith
- C B AdamsCAC B Adams
- R S GyeRGR S Gye
- 1 July 1975
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 38 (7) , 650-656
Abstract
The isolated human basilar artery suspended in Kreb's solution contracts to 5-hydroxy-tryptamine, noradrenaline, and histamine, which stimulate specific receptors. Normal human serum contains an unidentified contractile substance, and erythrocytes relax the artery. Serum and erythrocytes potentiate 5-HT contractions. This preparation is suitable for studying vasoactive substances released during vasospasm after subarachnoid haemorrhage.Keywords
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