Severity of cirrhosis and the relationship of α1-acid glycoprotein concentration to plasma protein binding of lidocaine
Authors:
- 1 March 1990
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 47 (3) , 366-370
Abstract
The concentration of alpha 1-acid glycoprotein, the major determinant of the plasma protein binding of basic drugs, and the extent of lidocaine protein binding was related to the severity of liver disease in 30 cirrhotic patients. In comparison with matched control subjects, alpha 1-acid glycoprotein concentration (77 +/- 7 versus 37 +/- 3 mg/dl; mean +/- SEM; p less than 0.01) and lidocaine binding (69% +/- 2% versus 35% +/- 2%; p less than 0.01) was markedly reduced. There was a significant negative correlation (r = 0.78; p less than 0.01) between free lidocaine and alpha 1-acid glycoprotein concentration. Furthermore, both were significantly related to the severity of liver disease, as assessed by use of the Child Turcotte classification.Keywords
This publication has 7 references indexed in Scilit:
- Measurement of Serum α1-Acid Glycoprotein and cei-Antitrypsin Desialylation in Liver DiseaseHepatology, 1983
- Changes in serum alpha1 antitrypsin, alpha1 acid glycoprotein and beta2 glycoprotein i in patients with malignant hepatocellular carcinomaCancer, 1979
- Increased Plasma Protein Binding of Propranolol and Chlorpromazine Mediated by Disease-Induced Elevations of Plasma α1Acid GlycoproteinNew England Journal of Medicine, 1978
- Plasma protein binding of basic drugsClinical Pharmacology & Therapeutics, 1977
- Protein Binding and Kinetics of Drugs in Liver DiseasesClinical Pharmacokinetics, 1977
- PLASMA-PROTEIN BINDING OF BASIC DRUGS .1. SELECTIVE DISPLACEMENT FROM ALPHA1-ACID GLYCOPROTEIN BY TRIS(2-BUTOXYETHYL) PHOSPHATE1977
- Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in HumansAnnals of Internal Medicine, 1973