Vitamin D, Parathyroid Hormone, and Sudden Cardiac Death

Authors:
  • RKRonit Katz
    Ronit Katz
  • MSMichael G. Shlipak
    Michael G. Shlipak
  • NSNona Sotoodehnia
    Nona Sotoodehnia
  • BPBruce M. Psaty
    Bruce M. Psaty
  • MSMark J. Sarnak
    Mark J. Sarnak
  • LFLinda F. Fried
    Linda F. Fried
  • MCMichel Chonchol
    Michel Chonchol
  • IBIan H. de Boer
    Ian H. de Boer
  • DEDaniel Enquobahrie
    Daniel Enquobahrie
  • DSDavid Siscovick
    David Siscovick
  • BKBryan Kestenbaum
    Bryan Kestenbaum
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Abstract
Recent studies have demonstrated greater risks of cardiovascular events and mortality among persons who have lower 25-hydroxyvitamin D (25-OHD) and higher parathyroid hormone (PTH) levels. We sought to evaluate the association between markers of mineral metabolism and sudden cardiac death (SCD) among the 2312 participants from the Cardiovascular Health Study who were free of clinical cardiovascular disease at baseline. We estimated associations of baseline 25-OHD and PTH concentrations individually and in combination with SCD using Cox proportional hazards models after adjustment for demographics, cardiovascular risk factors, and kidney function. During a median follow-up of 14 years, there were 73 adjudicated SCD events. The annual incidence of SCD was greater among subjects who had lower 25-OHD concentrations, 2 events per 1000 for 25-OHD ≥20 ng/mL and 4 events per 1000 for 25-OHD P =0.017) compared with participants with normal levels of PTH and 25-OHD. The combination of lower 25-OHD and higher PTH concentrations appears to be associated independently with SCD risk among older adults without cardiovascular disease.

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