Combination therapy with or without warfarin and dipyridamole for severe childhood IgA nephropathy: an RCT

Authors:
  • JGJapanese Pediatric IgA Nephropathy Treatment Study Group
    Japanese Pediatric IgA Nephropathy Treatment Study Group
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Abstract
Two previous randomized controlled trials showed that treatment of severe childhood immunoglobulin A (IgA) nephropathy using prednisolone with azathioprine, heparin-warfarin, or dipyridamole prevented the increase of sclerosed glomeruli. Prednisolone alone, however, did not prevent further increase. These studies indicated the importance of immunosuppressants in the treatment. An additional pilot study using mizoribine instead of azathioprine enabled us to complete 2 years of combined regimen. It showed non-numerical inferior effectiveness compared with the azathioprine regimen. Further examination of the additional efficacy of warfarin and dipyridamole was required.
Funding Information
  • Asahi Kasei Therapeutics Corporation (Lecture fees, Consulting fees, Grants and lecture fees, Lecture fees, Lecture fees, Lecture fees, Lecture fees, Lecture fees)
  • Eizai Co. (Grants, Grants, Grants)
  • Takeda Pharmaceutical Company (Lecture fees, Grants and lecture fees)
  • Boehringer Ingelheim Japan Co. (Lecture fees, Lecture fees)

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