Absorption and metabolism of nicotine from cigarettes.

Authors:
  • AAA K Armitage
    A K Armitage
  • CDC T Dollery
    C T Dollery
  • CGC F George
    C F George
  • THT H Houseman
    T H Houseman
  • PLP J Lewis
    P J Lewis
  • DTD M Turner
    D M Turner
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Abstract
Eight men volunteers each smoked a single cirgarette containing 14C-nicotine and gave arterial blood samples during and for 50 minutes after smoking. The maximum concentration of nicotine in the arterial blood ranged from 31 to 41 mug/l in four regular cigarette smokers who inhaled. Two non-smokers achieved maximum levels of 2 and 4 mug/l. On a separate occasion two of the inhalers received 1 mg. 14C-nicotine in 10 divided doses injected intravenously. In both cases the peak arterial nicotine concentrations bore a similar relationship to the intravenous dose, as did the peak nicotine concentrations to the retained doses during smoking.