The Relationship between Depressive Symptoms, Quality of Life and miRNAs 8 Years after Bariatric Surgery

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Abstract
(1) Background: There are conflicting results on whether weight loss after bariatric surgery (BS) might be associated with quality of life (QoL)/depressive symptomatology. We aim to determine whether BS outcomes are associated with QoL/depressive symptomatology in studied patients at the 8-year follow-up after BS, as well as their relationship with different serum proteins and miRNAs. (2) Methods: A total of 53 patients with class III obesity who underwent BS, and then classified into “good responders” and “non-responders” depending on the percentage of excess weight lost (%EWL) 8 years after BS (%EWL ≥ 50% and %EWL < 50%, respectively), were included. Basal serum miRNAs and different proteins were analysed, and patients completed tests to evaluate QoL/depressive symptomatology at 8 years after BS. (3) Results: The good responders group showed higher scores on SF-36 scales of physical functioning, role functioning—physical, role functioning—emotional, body pain and global general health compared with the non-responders. The expression of hsa-miR-101-3p, hsa-miR-15a-5p, hsa-miR-29c-3p, hsa-miR-144-3p and hsa-miR-19b-3p were lower in non-responders. Hsa-miR-19b-3p was the variable associated with the response to BS in a logistic regression model. (4) Conclusions: The mental health of patients after BS is limited by the success of the intervention. In addition, the expression of basal serum miRNAs related to depression/anxiety could predict the success of BS.
Funding Information
  • Malaga University (UMA20-FEDERJA-144, PI-0194-2017, C-0028-2018, RC-005-2020, DOC_00288, DOC_01095, FI19/00189)
  • Consejería de Salud y Familias, Junta de Andalucía (UMA20-FEDERJA-144, PI-0194-2017, C-0028-2018, RC-005-2020, DOC_00288, DOC_01095, FI19/00189)
  • FEDER funds (UMA20-FEDERJA-144, PI-0194-2017, C-0028-2018, RC-005-2020, DOC_00288, DOC_01095, FI19/00189)
  • Consejeria de Salud de Andalucia (UMA20-FEDERJA-144, PI-0194-2017, C-0028-2018, RC-005-2020, DOC_00288, DOC_01095, FI19/00189)
  • Consejería de Transformación Económica, Industria, Conocimiento y Universidades de Junta de Andalucía (UMA20-FEDERJA-144, PI-0194-2017, C-0028-2018, RC-005-2020, DOC_00288, DOC_01095, FI19/00189)
  • ISCIII (UMA20-FEDERJA-144, PI-0194-2017, C-0028-2018, RC-005-2020, DOC_00288, DOC_01095, FI19/00189)

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