The Deoxycytidine Pathway for Thymidylate Synthesis in Escherichia coli
Author:
- 1 November 2007
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 189 (21) , 7922-7926
Abstract
When thymidylate production is diminished by a mutation affecting dCTP deaminase, Escherichia coli is known to use an alternate pathway involving deoxycytidine as an intermediate. The pathway requires the gene for any of three nucleoside diphosphate kinases ( ndk , pykA , or pykF ) and the gene for a 5′-nucleotidase ( yfbR ).Keywords
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