Fecal Microbiota Transplantation for Treatment of Severe, Recurrent, and Refractory Clostridium difficile Infection in a Severely Immunocompromised Patient

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Abstract
Information on the safety of fecal microbiota transplantation (FMT) among immunocompromised patients with Clostridium difficile infection (CDI) is limited, and some have recommended avoiding FMT in this population. We report a case of severe, refractory CDI in an orthotopic heart transplant recipient with pre-existing CD4 lymphopenia. Our experience suggests that FMT can be safe and effective in treating CDI in immunocompromised patients with acute illness.

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