A Plurihormonal TSH-Producing Pituitary Tumor of Monoclonal Origin in a Patient with Hypothyroidism
Authors:
- Hidetoshi IkedaHIHidetoshi Ikeda
- Noriaki WatabeNWNoriaki Watabe
- Mitsunobu KannoMKMitsunobu Kanno
- Takashi YoshimotoTYTakashi Yoshimoto
- 8 May 2003
- journal article
- case report
- Published by S. Karger AG in Hormone Research in Paediatrics
- Vol. 59 (5) , 257-261
Abstract
Objective: A clinicopathological and clonal study of a pituitary tumor was made in a 26-year-old woman with chronic thyroiditis to differentiate TSH-producing adenoma from TSH hyperplasia. Methods: Tumor specimens were subjected to histopathological study and clonal analysis (HUMARA). Results: Immunohistochemical examination disclosed TSH-beta, PRL, GH, ACTH, FSH-beta, LH-beta, and alpha-subunit production in the adenoma cells. These heterogeneous phenotypes are characteristic of both thyrotroph hyperplasia and plurihormonal TSH-producing adenoma. However, the HUMARA method demonstrated monoclonality of the tumor cells. Conclusion: Monoclonality of the tumor cells proved that the pituitary tumor was plurihormonal TSH-producing adenoma, not TSH hyperplasia.Keywords
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