Effect of Oligomers Derived from Biodegradable Polyesters on Eco- and Neurotoxicity
Open Access
- 21 April 2023
- journal article
- research article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 24 (6) , 2721-2729
Abstract
Biodegradable polymers are eco-friendly materials and have attracted attention for use in a sustainable society because they are not accumulated in the environment. Although the characteristics of biodegradable polymers have been assessed well, the effects of their degradation products have not. Herein, we comprehensively evaluated the chemical toxicities of biodegradable polyester, polycaprolactone (PCL), and synthetic oligocaprolactones (OCLs) with different degrees of polymerization. While the PCL did not show any adverse effects on various organisms, high levels of shorter OCLs and the monomer (1 μg/mL for freshwater microorganisms and 1 mg/mL for marine algae and mammalian cells) damaged the tested organisms, including freshwater microorganisms, marine algae, and mammalian cells, which indicated the toxicities of the degradation products under unnaturally high concentrations. These results highlight the need for a further understanding of the effects of the degradation products resulting from biodegradable polyesters to ensure a genuinely sustainable society.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology (JPMXP1122714694)
- Ministry of the Environment, Government of Japan (1RF-2202)
- Exploratory Research for Advanced Technology (JPMJER1602)
- Japan Society for the Promotion of Science (20H05732, 20H05734, 20H05735)
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