Potent Antidopaminergic Activity of Estradiol at the Pituitary Level on Prolactin Release
Authors:
- 9 June 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4346) , 1173-1175
Abstract
Prior incubation of rat anterior pituitary cells with 17β-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone-induced prolactin release. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. Prolactin secretion by pituitary cells in primary culture could possibly serve as an easily accessible model of a system under dopaminergic control.Keywords
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