Hypotensive and Vasorelaxing Activities of a Lectin from the Edible Mushroom Tricholoma mongolicum

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Abstract
A lectin, which exerted a hypotensive action in rats after intravenous injection via the jugular vein, was isolated from the mycelia of the edible mushroomTricholoma mongolicum.The lectin possessed a molecular weight of 37 K and its hypotensive activity was dose‐dependent. Administration of the lectin at a dose of 10 mg/kg body weight caused a mean arterial blood pressure reduction of 95.3±7.4 mmHg. The lectin's hypotensive action was not mediated via autonomic ganglion transmission, α‐adrenoceptors, β‐adrenoceptors, cholinergic receptors, histaminergic receptors, nor the renin‐angiotensin system, but it was probably mediated through vasorelaxation via adenosine A2 receptors and/or nitric oxide production.

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