Exercise training induces mild skeletal muscle adaptations without altering disease progression in a TDP-43 mouse model

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Abstract
This is the first study to investigate the capacity of symptomatic rNLS8 mice, which develop ALS-reminiscent TDP-43 pathology and motor dysfunction, to perform exercise training. We demonstrate that despite the ALS-reminiscent aggressive disease progression characterizing the rNLS8 mouse model, rNLS8 mice are capable of performing mild-to-moderate endurance treadmill training for at least 3–4 wk. We demonstrate that exercise training induces several minor skeletal muscle adaptations without delaying disease progression in rNLS8 mice.
Funding Information
  • Ross Maclean Fellowship
  • Bill Guest FightMND Mid-Career Development Fellowship
  • Brazil Family Program for Neurology
  • Deakin University (Alfred Deakin PostDoc Fellowship)
  • Deakin University | Institute for Physical Activity and Nutrition
  • Neurological Foundation of New Zealand (Philip Wrightson Fellowship)
  • Australian National Health and Medical Research Council (1124005)
  • Onassis Foundation Greece

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